abstract：BACKGROUND:Loss-of-function mutations in SCN5A are associated in ∼20% of Brugada syndrome (BrS) patients. Copy number variations (CNVs) have been shown to be associated with several inherited arrhythmia syndromes. OBJECTIVE:The purpose of this study was to investigate SCN5A CNVs among BrS probands. METHODS:The study ...

journal_title：Heart rhythm

authors： Sonoda K,Ohno S,Ozawa J,Hayano M,Hattori T,Kobori A,Yahata M,Aburadani I,Watanabe S,Matsumoto Y,Makiyama T,Horie M

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Due to rapid expansion of clinical genetic testing, an increasing number of genetic variants of undetermined significance and unclear diagnostic value are being identified in children. Variants found in genes associated with heritable channelopathies, such as long QT syndrome (LQTS), are particularly difficu...

journal_title：Heart rhythm

authors： Landstrom AP,Fernandez E,Rosenfeld JA,Yang Y,Dailey-Schwartz AL,Miyake CY,Allen HD,Penny DJ,Kim JJ

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Experience with retrieval of the Micra transcatheter pacing system (TPS) is limited because of its relatively newer technology. Although abandonment of the TPS at end of life is recommended, certain situations such as endovascular infection or device embolization warrant retrieval. OBJECTIVE:The purpose of ...

journal_title：Heart rhythm

authors： Afzal MR,Daoud EG,Cunnane R,Mulpuru SK,Koay A,Hussain A,Omar R,Wei KK,Amin A,Kidwell G,Patel N,Love C,Lloyd M,Sterliński M,Goldbarg S,Leal MA,Gabriels J,Patel A,Jadonath R,Grubman E,Crossley G,Pepper C,Lakkire

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Early detection of cardiac involvement in sarcoidosis is difficult but essential to achieve optimal treatment. Signal-averaged electrocardiography (SAECG) can detect subtle cardiac electrical abnormalities termed late potentials (LPs) and would be useful for the early diagnosis of cardiac involvement. OBJEC...

journal_title：Heart rhythm

authors： Yodogawa K,Seino Y,Ohara T,Iwasaki YK,Hayashi M,Miyauchi Y,Azuma A,Shimizu W

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias are the most common cause of death in patients with repaired tetralogy of Fallot (TOF), but predicting those at risk remains a challenge. An electrophysiology study (EPS) has been proposed to risk stratify patients with TOF. OBJECTIVE:We sought to evaluate a perioperative EPS-gu...

journal_title：Heart rhythm

authors： Sandhu A,Ruckdeschel E,Sauer WH,Collins KK,Kay JD,Khanna A,Jaggers J,Campbell D,Mitchell M,Nguyen DT

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Despite improving algorithms, inappropriate shocks for supraventricular tachycardia (SVT) still occur in a significant number of patients with implantable cardioverter-defibrillators (ICDs). This makes the discovery of novel discriminators that use existing ICD hardware an attractive proposition. OBJECTIVE:...

journal_title：Heart rhythm

authors： Caldwell J,Gula L,Ali FS,Miranda RI,Abdollah H,Baranchuk A,Michael K,Simpson C,Redfearn DP

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) requires a high percentage of ventricular pacing (%Vp) to maximize its clinical benefits. Atrial fibrillation (AF) has been shown to reduce %Vp in CRT due to competition with irregular intrinsic atrioventricular (AV) conduction. We report the results of a prospective r...

journal_title：Heart rhythm

authors： Plummer CJ,Frank CM,Bári Z,Al Hebaishi YS,Klepfer RN,Stadler RW,Ghosh S,Liu S,Mittal S

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Pulmonary vein isolation (PVI) is a cornerstone ablation strategy in the management of patients with atrial fibrillation (AF). Consensus guidelines and statements recommend PVI during the index catheter ablation procedure in patients with paroxysmal and persistent AF. OBJECTIVE:The objective of this analysi...

journal_title：Heart rhythm

authors： Tondo C,Iacopino S,Pieragnoli P,Molon G,Verlato R,Curnis A,Landolina M,Allocca G,Arena G,Fassini G,Sciarra L,Luzi M,Manfrin M,Padeletti L,ClinicalService 1STOP Project Investigators.

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) has been performed safely in patients without MRI-conditional cardiac implantable electronic devices (CIEDs), but experience specifically with cardiac magnetic resonance imaging (CMR) is limited in this patient population. OBJECTIVE:Evaluate the safety of CMR in non-MRI-cond...

journal_title：Heart rhythm

authors： Do DH,Eyvazian V,Bayoneta AJ,Hu P,Finn JP,Bradfield JS,Shivkumar K,Boyle NG

更新日期：2018-02-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia diagnosed and treated in the world. The treatment of patients' symptoms as well as the prevention of stroke and heart failure is dependent on accurate detection and characterization of AF. A variety of electrocardiographic (ECG) monitoring techniques are b...

journal_title：Heart rhythm

authors： Lee R,Mittal S

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:In general, the prognosis is poor for pediatric patients who experience out-of-hospital (OOH) cardiac arrest, with survival rates of 12% to 29%. OBJECTIVE:The purpose of this study was to describe the causes and outcomes of pediatric patients with documented ventricular fibrillation (VF) at resuscitation fr...

journal_title：Heart rhythm

authors： Silka MJ,Kobayashi RL,Hill AC,Bar-Cohen Y

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:An ischemic etiology of heart failure (HF) has been associated with reduced left ventricular reverse remodeling after cardiac resynchronization therapy (CRT). OBJECTIVE:The purpose of this study was to assess the relationship between the etiology of HF and reverse remodeling and outcome after CRT. METHODS:...

journal_title：Heart rhythm

authors： Martens P,Nijst P,Verbrugge FH,Dupont M,Tang WHW,Mullens W

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:In patients with ventricular tachycardia or ventricular fibrillation (VT/VF) electrical storm (ES) undergoing catheter ablation (CA), hypotension due to refractory VT/VF, use of anesthesia, and cardiac stunning due to repeated implantable cardioverter-defibrillator shocks might precipitate acute hemodynamic ...

journal_title：Heart rhythm

authors： Enriquez A,Liang J,Gentile J,Schaller RD,Supple GE,Frankel DS,Garcia FC,Wald J,Birati EY,Rame JE,Bermudez C,Callans DJ,Marchlinski FE,Santangeli P

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Frequent premature ventricular complexes (PVCs) can induce or worsen left ventricular (LV) systolic dysfunction. OBJECTIVE:The purpose of this study was to identify the clinical pattern of patients having a "pure PVC-induced" cardiomyopathy at presentation. METHODS:This prospective multicenter study includ...

journal_title：Heart rhythm

authors： Penela D,Fernández-Armenta J,Aguinaga L,Tercedor L,Ordoñez A,Bisbal F,Acosta J,Rossi L,Borras R,Doltra A,Ortiz-Pérez JT,Bosch X,Perea RJ,Prat-González S,Soto-Iglesias D,Tolosana JM,Vassanelli F,Cabrera M,Linhart M,M

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Class 1 antiarrhythmic drugs are highly effective in restoring and maintaining sinus rhythm in atrial fibrillation patients but carry a risk of ventricular tachyarrhythmia. The antianginal agent ranolazine is a prototypic atrial-selective voltage-gated Na+ channel blocker but the mechanisms underlying its at...

journal_title：Heart rhythm

authors： Caves RE,Cheng H,Choisy SC,Gadeberg HC,Bryant SM,Hancox JC,James AF

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Frequent premature ventricular complexes (PVCs) have been associated with increased mortality. However, the optimal approach to the risk stratification of these patients is unclear. OBJECTIVE:The purpose of this study was to prospectively assess the use of cardiac magnetic resonance imaging (MRI) and progra...

journal_title：Heart rhythm

authors： Yokokawa M,Siontis KC,Kim HM,Stojanovska J,Latchamsetty R,Crawford T,Jongnarangsin K,Ghanbari H,Cunnane R,Chugh A,Pelosi F Jr,Oral H,Morady F,Bogun F

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that using frequent invasive measures of pressure in patients with heart failure results in improved outcomes compared to traditional measures. Admittance, a measure of volume derived from preexisting defibrillation leads, is proposed as a new technique to monitor cardiac hemodyn...

journal_title：Heart rhythm

authors： Haines DE,Wong W,Canby R,Jewell C,Houmsse M,Pederson D,Sugeng L,Porterfield J,Kottam A,Pearce J,Valvano J,Michalek J,Trevino A,Sagar S,Feldman MD

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:An early failure of the Biotronik Linox S/SD implantable cardioverter-defibrillator (ICD) lead has been reported. We have also experienced several cases with early failure of Linox leads. OBJECTIVE:Our aim was to assess the longevity of Linox S/SD (Biotronik, Berlin, Germany) compared with Sprint Fidelis (M...

journal_title：Heart rhythm

authors： Kawada S,Nishii N,Morimoto Y,Miyoshi A,Tachibana M,Sugiyama H,Nakagawa K,Watanabe A,Morita H,Ito H

更新日期：2017-10-01 00:00:00

abstract：:The underlying mechanisms and temporal course of complete heart block (CHB) after blunt cardiac injuries (BCIs) are poorly understood, and a systematic analysis of available data is lacking. In this systematic review, PubMed was searched for publications of reported cases of CHB-BCI analyzing clinical findings, electr...

journal_title：Heart rhythm

authors： Ali H,Furlanello F,Lupo P,Foresti S,De Ambroggi G,Epicoco G,Semprini L,Fundaliotis A,Cappato R

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Asymptomatic cerebral embolism (ACE) is sometimes detected after cryoballoon ablation of atrial fibrillation. The removal of air bubbles from the cryoballoon before utilization may reduce the rate of ACE. OBJECTIVE:This study aims to compare the incidence of ACE between a conventional and a novel balloon ma...

journal_title：Heart rhythm

authors： Tokuda M,Matsuo S,Kato M,Sato H,Oseto H,Okajima E,Ikewaki H,Isogai R,Tokutake K,Yokoyama K,Narui R,Tanigawa SI,Yamashita S,Inada K,Yoshimura M,Yamane T

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Left atrial appendage (LAA) occlusion with WATCHMAN has emerged as viable alternative to vitamin K antagonists in randomized controlled trials. OBJECTIVE:EWOLUTION was designed to provide data in routine practice from a prospective multicenter registry. METHODS:A total of 1025 patients scheduled for a WATC...

journal_title：Heart rhythm

authors： Boersma LV,Ince H,Kische S,Pokushalov E,Schmitz T,Schmidt B,Gori T,Meincke F,Protopopov AV,Betts T,Foley D,Sievert H,Mazzone P,De Potter T,Vireca E,Stein K,Bergmann MW,EWOLUTION Investigators.

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Data evaluating repeat radiofrequency ablation (>1RFA) of ventricular tachycardia (VT) are limited. OBJECTIVE:The purpose of this study was to determine the safety and outcomes of VT >1RFA in patients with structural heart disease. METHODS:Patients with structural heart disease undergoing VT RFA at 12 cent...

journal_title：Heart rhythm

authors： Tzou WS,Tung R,Frankel DS,Di Biase L,Santangeli P,Vaseghi M,Bunch TJ,Weiss JP,Tholakanahalli VN,Lakkireddy D,Vunnam R,Dickfeld T,Mathuria N,Tedrow U,Vergara P,Vakil K,Nakahara S,Burkhardt JD,Stevenson WG,Callans DJ

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Patients with atrial fibrillation (AF) experience an increased risk of heart failure (HF). However, data are lacking on current trends in the risk of HF after AF. OBJECTIVE:The purpose of this study was to describe the temporal trends in HF occurrence after AF in a community cohort of patients with incident...

journal_title：Heart rhythm

authors： Chamberlain AM,Gersh BJ,Alonso A,Kopecky SL,Killian JM,Weston SA,Roger VL

更新日期：2017-06-01 00:00:00

abstract：:Spinal cord injury is a clinical syndrome encountered frequently in trauma centers and is accompanied by both acute and chronic heart rhythm abnormalities. The injury is characterized by sympathetic nervous system impairment with preservation of parasympathetic output via the vagus nerve. Severe bradycardia in the for...

journal_title：Heart rhythm

authors： Manogue M,Hirsh DS,Lloyd M

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Complete atrioventricular block (CAVB) causes arrhythmogenic remodeling and increases the risk of torsades de pointes arrhythmias. MicroRNAs (miRNAs) are key regulators of gene expression that contribute to cardiac remodeling. OBJECTIVE:The purpose of this study was to assess miRNA changes after CAVB and id...

journal_title：Heart rhythm

authors： Duong E,Xiao J,Qi XY,Nattel S

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Interleukin 1β (IL-1β) is a key regulator of the inflammatory response after myocardial infarction (MI) by modulating immune cell recruitment, cytokine production, and extracellular matrix turnover. Elevated levels of IL-1β are associated with adverse remodeling, and inhibition of IL-1 signaling after MI res...

journal_title：Heart rhythm

authors： De Jesus NM,Wang L,Lai J,Rigor RR,Francis Stuart SD,Bers DM,Lindsey ML,Ripplinger CM

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Endocardial mapping tools use variable interelectrode resolution, whereas body surface mapping tools use narrow bandpass filtering (BPF) to map fibrillatory mechanisms established by high-resolution optical imaging. OBJECTIVE:The purpose of this study was to study the effect of resolution and BPF on the und...

journal_title：Heart rhythm

authors： King B,Porta-Sánchez A,Massé S,Zamiri N,Balasundaram K,Kusha M,Jackson N,Haldar S,Umapathy K,Nanthakumar K

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Focal impulse and rotor modulation (FIRM) was based on the premise that atrial fibrillation (AF) is sustained by rotors that are sufficiently stable to be eliminated by targeted ablation. Early experience reported high success as compared to conventional strategies. OBJECTIVE:The purpose of this study was t...

journal_title：Heart rhythm

authors： Steinberg JS,Shah Y,Bhatt A,Sichrovsky T,Arshad A,Hansinger E,Musat D

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Limited data exist on cryoablation of atrial fibrillation (Cryo-AF) using the newly available third-generation (Arctic Front Advance-Short Tip [AFA-ST]) cryoballoon. OBJECTIVE:In this multicenter study, we evaluated the safety and efficacy of Cryo-AF using the AFA-ST vs the second-generation (Arctic Front A...

journal_title：Heart rhythm

authors： Aryana A,Kowalski M,O'Neill PG,Koo CH,Lim HW,Khan A,Hokanson RB,Bowers MR,Kenigsberg DN,Ellenbogen KA,Cryo-DOSING Investigators.

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The infusion of adenosine triphosphate after radiofrequency (RF) pulmonary vein (PV) isolation (PVI), which may result in acute transient PV-atrium reconnection, can unmask dormant conduction. OBJECTIVE:The purpose of this study was to compare the incidence and characteristics of dormant conduction after cr...

journal_title：Heart rhythm

authors： Tokuda M,Matsuo S,Isogai R,Uno G,Tokutake K,Yokoyama K,Kato M,Narui R,Tanigawa S,Yamashita S,Inada K,Yoshimura M,Yamane T

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The increased risk of stroke and cognitive impairment associated with atrial fibrillation (AF) is well documented. However, there is a paucity of research investigating the relations between AF and brain morphology. OBJECTIVE:The purpose of this study was to investigate the association between AF and brain ...

journal_title：Heart rhythm

authors： Piers RJ,Nishtala A,Preis SR,DeCarli C,Wolf PA,Benjamin EJ,Au R

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Focal impulse and rotor modulation (FIRM) has been proposed as a novel approach for the treatment of atrial fibrillation (AF). OBJECTIVE:This study aimed to investigate the efficacy of FIRM as a stand-alone procedure for the treatment of paroxysmal AF. METHODS:A total of 27 patients with paroxysmal AF unde...

journal_title：Heart rhythm

authors： Berntsen RF,Håland TF,Skårdal R,Holm T

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Catheter ablation is less successful for treatment of persistent atrial fibrillation (PersAF) than for paroxysmal atrial fibrillation. Some studies suggest that left atrial appendage (LAA) isolation in addition to pulmonary vein isolation (PVI) is required to maximize the benefits for PersAF after ablation. ...

journal_title：Heart rhythm

authors： Romanov A,Pokushalov E,Elesin D,Bogachev-Prokophiev A,Ponomarev D,Losik D,Bayramova S,Strelnikov A,Shabanov V,Pidanov O,Kropotkin E,Ivanickii E,Karaskov A,Steinberg JS

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Left atrial appendage (LAA) has recently been of significant focus because of the development of the LAA closure device. OBJECTIVE:The purpose of this study was to test the hypothesis that atrial fibrillation (AF) leads to a morphologic change in the LAA and to investigate the characteristics of LAA morphol...

journal_title：Heart rhythm

authors： Kishima H,Mine T,Takahashi S,Ashida K,Ishihara M,Masuyama T

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Verification of bidirectional block is important for mitral isthmus (MI) ablation. However, recurrent perimitral reentry exists despite apparently MI block. OBJECTIVE:The purpose of this study was to identify and investigate the characteristics of the ridge breakthrough despite apparent bidirectional MI blo...

journal_title：Heart rhythm

authors： Jiang CX,Dong JZ,Long DY,Yu RH,Tang RB,Sang CH,Ning M,Li SN,Guo XY,Du X,Bai R,Liu N,Wu JH,Ma CS

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Tissue refractoriness to conduction is a crucial electrophysiological factor in determining susceptibility to fibrillation. The relationship between atrial refractoriness and future onset of atrial fibrillation (AF) has not been well studied. OBJECTIVES:We investigated whether atrial effective refractory pe...

journal_title：Heart rhythm

authors： Lee JM,Lee H,Janardhan AH,Park J,Joung B,Pak HN,Lee MH,Kim SS,Hwang HJ

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Diabetes and obesity are associated with an increased risk of arrhythmia and sudden cardiac death. Abnormal lipid accumulation is observed in cardiomyocytes of obese and diabetic patients, which may contribute to arrhythmia, but the mechanisms are poorly understood. A transgenic mouse model of cardiac lipid ...

journal_title：Heart rhythm

authors： Joseph LC,Subramanyam P,Radlicz C,Trent CM,Iyer V,Colecraft HM,Morrow JP

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Use of nonfluoroscopic 3-dimensional electroanatomic mapping (NF-3DEAM) in patients with congenital heart defects (CHDs) is not well reported. OBJECTIVE:The purpose of this study was to evaluate the feasibility, accuracy, and safety of NF-3DEAM in patients with CHDs. METHODS:Retrospective review of electro...

journal_title：Heart rhythm

authors： Bharmanee A,Gowda S,Singh HR

更新日期：2016-08-01 00:00:00

abstract：:Catheter ablation of ventricular tachycardia (VT) has evolved in recent years, especially in patients with ischemic heart disease. Data from prospective studies show that VT catheter ablation reduces the risk of recurrent VT; however, there is a paucity of data on the effect of VT catheter ablation on mortality and pa...

journal_title：Heart rhythm

authors： Pokorney SD,Friedman DJ,Calkins H,Callans DJ,Daoud EG,Della-Bella P,Jackson KP,Shivkumar K,Saba S,Sapp J,Stevenson WG,Al-Khatib SM

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Dofetilide is a class III antiarrhythmic drug approved for the treatment of atrial fibrillation (AF). Dofetilide-induced corrected QT (QTc) interval prolongation is a surrogate for the degree of drug effect, but the relationships between drug-induced QTc interval prolongation, pharmacological cardioversion (...

journal_title：Heart rhythm

authors： Huang HD,Waks JW,Steinhaus DA,Zimetbaum P

更新日期：2016-07-01 00:00:00